2013

  1. Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland, Peter J Detloff, David E Housman and Gillian P Bates. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc Natl Acad Sci U S A, 110 (6): 2366-70, 2013.
  2. Christopher W Ng, Ferah Yildirim, Yoon Sing Yap, Simona Dalin, Bryan J Matthews, Patricio J Velez, Adam Labadorf, David E Housman and Ernest Fraenkel. Extensive changes in DNA methylation are associated with expression of mutant huntingtin. Proc Natl Acad Sci U S A, 110 (6): 2354-9, 2013.
  3. Emily M Sontag, Lukasz A Joachimiak, Zhiqun Tan, Anthony Tomlinson, David E Housman, Charles G Glabe, Steven G Potkin, Judith Frydman and Leslie M Thompson. Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci U S A, 110 (8): 3077-82, 2013.
  4. Adel Tabchy, Nevine Eltonsy, David E Housman and Gordon B Mills. Systematic identification of combinatorial drivers and targets in cancer cell lines. PLoS One, 8 (4): e60339, 2013.
  5. Marka van Blitterswijk, Eric T Wang, Brad A Friedman, Pamela J Keagle, Patrick Lowe, Ashley Lyn Leclerc, Leonard H van den Berg, David E Housman, Jan H Veldink and John E Landers. Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq. PLoS One, 8 (4): e60788, 2013.
  6. Malini Vashishtha, Christopher W Ng, Ferah Yildirim, Theresa A Gipson, Ian H Kratter, Laszlo Bodai, Wan Song, Alice Lau, Adam Labadorf, Annie Vogel-Ciernia, Juan Troncosco, Christopher A Ross, Gillian P Bates, Dimitri Krainc, Ghazaleh Sadri-Vakili, Steven Finkbeiner, J Lawrence Marsh, David E Housman, Ernest Fraenkel and Leslie M Thompson. Targeting H3K4 trimethylation in Huntington disease. Proc Natl Acad Sci U S A, 110 (32): E3027-36, 2013.
  7. Katie Rose Boissonneault, Brooks M Henningsen, Stephen S Bates, Deborah L Robertson, Sean Milton, Jerry Pelletier, Deborah A Hogan and David E Housman. Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries. BMC Mol Biol, 14 (1): 25, 2013.

2012

  1. H J Jun, J Acquaviva, D Chi, J Lessard, H Zhu, S Woolfenden, R T Bronson, R Pfannl, F White, D E Housman, L Iyer, C A Whittaker, A Boskovitz, A Raval and A Charest. Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme. Oncogene, 31 (25): 3039-50, 2012.
  2. Zachary R Crook and David E Housman. Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice. Proc Natl Acad Sci U S A, 109 (19): 7487-92, 2012.
  3. Maja M Janas, Eric Wang, Tara Love, Abigail S Harris, Kristen Stevenson, Karlheinz Semmelmann, Jonathan M Shaffer, Po-Hao Chen, John G Doench, Subrahmanyam V B K Yerramilli, Donna S Neuberg, Dimitrios Iliopoulos, David E Housman, Christopher B Burge and Carl D Novina. Reduced expression of ribosomal proteins relieves microRNA-mediated repression. Mol Cell, 46 (2): 171-86, 2012.
  4. Eric T Wang, Neal A L Cody, Sonali Jog, Michela Biancolella, Thomas T Wang, Daniel J Treacy, Shujun Luo, Gary P Schroth, David E Housman, Sita Reddy, Eric L'ecuyer and Christopher B Burge. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell, 150 (4): 710-24, 2012.

2011

  1. Jaime Acquaviva, Hyun Jung Jun, Julie Lessard, Rolando Ruiz, Haihao Zhu, Melissa Donovan, Steve Woolfenden, Abraham Boskovitz, Ami Raval, Roderick T Bronson, Rolf Pfannl, Charles A Whittaker, David E Housman and Al Charest. Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation. Cancer Res, 71 (23): 7198-206, 2011.

2010

  1. Eric C Wooten, Lakshmanan K Iyer, Maria Claudia Montefusco, Alyson Kelley Hedgepeth, Douglas D Payne, Navin K Kapur, David E Housman, Michael E Mendelsohn and Gordon S Huggins. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. PLoS One, 5 (1): e8830, 2010.
  2. Jill R Crittenden, Denise E Dunn, Farhan I Merali, Ben Woodman, Michael Yim, Anna E Borkowska, Matthew P Frosch, Gillian P Bates, David E Housman, Donald C Lo and Ann M Graybiel. CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. Hum Mol Genet, 19 (9): 1756-65, 2010.
  3. Amy L Williams, David E Housman, Martin C Rinard and David K Gifford. Rapid haplotype inference for nuclear families. Genome Biol, 11 (10): R108, 2010.

2009

  1. D Brocklebank, J Gay'an, J M Andresen, S A Roberts, A B Young, S R Snodgrass, J B Penney, M A Ramos-Arroyo, J J Cha, H D Rosas, S M Hersch, A Feigin, S S Cherny, N S Wexler, D E Housman, L R Cardon and International-Venezuela Collaborative Research Group. Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications. Am J Med Genet B Neuropsychiatr Genet, 150B (3): 425-9, 2009.
  2. I Peter, A Kelley-Hedgepeth, G S Huggins, D E Housman, M E Mendelsohn, J A Vita, R S Vasan, D Levy, E J Benjamin and G F Mitchell. Association between arterial stiffness and variations in oestrogen-related genes. J Hum Hypertens, 23 (10): 636-44, 2009.
  3. Haihao Zhu, Jaime Acquaviva, Pranatartiharan Ramachandran, Abraham Boskovitz, Steve Woolfenden, Rolf Pfannl, Roderick T Bronson, John W Chen, Ralph Weissleder, David E Housman and Al Charest. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A, 106 (8): 2712-6, 2009.
  4. Paolo Paganetti, Andreas Weiss, Monique Trapp, Ina Hammerl, Doroth'ee Bleckmann, Ruth A Bodner, Shanie Coven-Easter, David E Housman and Christian N Parker. Development of a method for the high-throughput quantification of cellular proteins. Chembiochem, 10 (10): 1678-88, 2009.

2008

  1. Inga Peter, Alyson Kelley-Hedgepeth, Caroline S Fox, L Adrienne Cupples, Gordon S Huggins, David E Housman, Richard H Karas, Michael E Mendelsohn, Daniel Levy and Joanne M Murabito. Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels. J Clin Endocrinol Metab, 93 (7): 2779-85, 2008.
  2. Javier Gay'an, Denise Brocklebank, J Michael Andresen, Gorka Alkorta-Aranburu, US-Venezuela Collaborative Research Group, M Zameel Cader, Simone A Roberts, Stacey S Cherny, Nancy S Wexler, Lon R Cardon and David E Housman. Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. Genet Epidemiol, 32 (5): 445-53, 2008.
  3. John R Mills, Yoshitaka Hippo, Francis Robert, Samuel M H Chen, Abba Malina, Chen-Ju Lin, Ulrike Trojahn, Hans-Guido Wendel, Al Charest, Roderick T Bronson, Scott C Kogan, Robert Nadon, David E Housman, Scott W Lowe and Jerry Pelletier. mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A, 105 (31): 10853-8, 2008.
  4. Bret R Williams, Vineet R Prabhu, Karen E Hunter, Christina M Glazier, Charles A Whittaker, David E Housman and Angelika Amon. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science, 322 (5902): 703-9, 2008.

2007

  1. J M Andresen, J Gay'an, S S Cherny, D Brocklebank, G Alkorta-Aranburu, E A Addis, US-Venezuela Collaborative Research Group, L R Cardon, D E Housman and N S Wexler. Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds. J Med Genet, 44 (1): 44-50, 2007.
  2. J Michael Andresen, Javier Gay'an, Luc Djouss'e, Simone Roberts, Denise Brocklebank, Stacey S Cherny, US-Venezuela Collaborative Research Group, HD MAPS Collaborative Research Group, Lon R Cardon, James F Gusella, Marcy E MacDonald, Richard H Myers, David E Housman and Nancy S Wexler. The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset. Ann Hum Genet, 71 (Pt 3): 295-301, 2007.
  3. Inga Peter, Gordon S Huggins, Amanda M Shearman, Arthur Pollak, Christopher H Schmid, L Adrienne Cupples, Serkalem Demissie, Richard D Patten, Richard H Karas, David E Housman, Michael E Mendelsohn, Ramachandran S Vasan and Emelia J Benjamin. Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene. Hypertension, 49 (5): 1000-6, 2007.
  4. Myra Coufal, Michele M Maxwell, Deborah E Russel, Allison M Amore, Stephen M Altmann, Zane R Hollingsworth, Anne B Young, David E Housman and Aleksey G Kazantsev. Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments. J Biomol Screen, 12 (3): 351-60, 2007.
  5. Wolfgang Bergmeier, Tobias Goerge, Hong-Wei Wang, Jill R Crittenden, Andrew C W Baldwin, Stephen M Cifuni, David E Housman, Ann M Graybiel and Denisa D Wagner. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest, 117 (6): 1699-707, 2007.
  6. Vanita Chopra, Jonathan H Fox, Greg Lieberman, Kathryn Dorsey, Wayne Matson, Peter Waldmeier, David E Housman, Aleksey Kazantsev, Anne B Young and Steven Hersch. A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. Proc Natl Acad Sci U S A, 104 (42): 16685-9, 2007.

2006

  1. Serkalem Demissie, L Adrienne Cupples, Amanda M Shearman, Kristen M Gruenthal, Inga Peter, Christopher H Schmid, Richard H Karas, David E Housman, Michael E Mendelsohn and Jose M Ordovas. Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study. Atherosclerosis, 185 (1): 210-8, 2006.
  2. Amanda M Shearman, Jackie A Cooper, Paul J Kotwinski, George J Miller, Steve E Humphries, Kristin G Ardlie, Barbara Jordan, Kathryn Irenze, Kathryn L Lunetta, Stephanie C E Schuit, Andr'e G Uitterlinden, Huibert A P Pols, Serkalem Demissie, L Adrienne Cupples, Michael E Mendelsohn, Daniel Levy and David E Housman. Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circ Res, 98 (5): 590-2, 2006.
  3. Ruth A Bodner, Tiago Fleming Outeiro, Stephen Altmann, Michele M Maxwell, Stephanie H Cho, Bradley T Hyman, Pamela J McLean, Anne B Young, David E Housman and Aleksey G Kazantsev. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci U S A, 103 (11): 4246-51, 2006.
  4. Ruth A Bodner, David E Housman and Aleksey G Kazantsev. New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions. Cell Cycle, 5 (14): 1477-80, 2006.
  5. Keiko Horiuchi, Michihisa Umetani, Takashi Minami, Hiroto Okayama, Shinji Takada, Masayuki Yamamoto, Hiroyuki Aburatani, Patrick C Reid, David E Housman, Takao Hamakubo and Tatsuhiko Kodama. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A, 103 (46): 17278-83, 2006.

2005

  1. Xiaoqian Zhang, Donna L Smith, Anatoli B Meriin, Sabine Engemann, Deborah E Russel, Margo Roark, Shetia L Washington, Michele M Maxwell, J Lawrence Marsh, Leslie Michels Thompson, Erich E Wanker, Anne B Young, David E Housman, Gillian P Bates, Michael Y Sherman and Aleksey G Kazantsev. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A, 102 (3): 892-7, 2005.
  2. Dirk Prawitt, Thorsten Enklaar, Barbara G"artner-Rupprecht, Christian Spangenberg, Monika Oswald, Ekkehart Lausch, Peter Schmidtke, Dirk Reutzel, Stephan Fees, Rob Lucito, Maria Korzon, Izabela Brozek, Janusz Limon, David E Housman, Jerry Pelletier and Bernhard Zabel. Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. Proc Natl Acad Sci U S A, 102 (11): 4085-90, 2005.
  3. Qiong Yang, Chao-Qiang Lai, Laurence Parnell, L Adrienne Cupples, Xian Adiconis, Yueping Zhu, Peter W F Wilson, David E Housman, Amanda M Shearman, Ralph B D'Agostino and Jose M Ordovas. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. J Lipid Res, 46 (7): 1416-25, 2005.
  4. Amanda M Shearman, Serkalem Demissie, L Adrienne Cupples, Inga Peter, Christopher H Schmid, Jose M Ordovas, Michael E Mendelsohn and David E Housman. Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level. Hum Mol Genet, 14 (16): 2405-13, 2005.
  5. Dirk Prawitt, Thorsten Enklaar, Barbara G"artner-Rupprecht, Christian Spangenberg, Ekkehart Lausch, Dirk Reutzel, Stephan Fees, Maria Korzon, Izabela Brozek, Janusz Limon, David E Housman, Jerry Pelletier and Bernhard Zabel. Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor. Nat Genet, 37 (8): 785-6; author reply 786-7, 2005.
  6. Caroline S Fox, Qiong Yang, L Adrienne Cupples, Chao-Yu Guo, Larry D Atwood, Joanne M Murabito, Daniel Levy, Michael E Mendelsohn, David E Housman and Amanda M Shearman. Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study. J Clin Endocrinol Metab, 90 (11): 6257-62, 2005.
  7. Amanda M Shearman, Jackie A Cooper, Paul J Kotwinski, Steve E Humphries, Michael E Mendelsohn, David E Housman and George J Miller. Estrogen receptor alpha gene variation and the risk of stroke. Stroke, 36 (10): 2281-2, 2005.
  8. Inga Peter, Amanda M Shearman, Deborah R Zucker, Christopher H Schmid, Serkalem Demissie, L Adrienne Cupples, Martin G Larson, Ramachandran S Vasan, Ralph B D'Agostino, Richard H Karas, Michael E Mendelsohn, David E Housman and Daniel Levy. Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study. J Hypertens, 23 (12): 2193-200, 2005.
  9. Inga Peter, Amanda M Shearman, Ramachandran S Vasan, Deborah R Zucker, Christopher H Schmid, Serkalem Demissie, L Adrienne Cupples, Jeffrey T Kuvin, Richard H Karas, Michael E Mendelsohn, David E Housman and Emelia J Benjamin. Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women. Am J Hypertens, 18 (11): 1388-95, 2005.

2004

  1. Xiao-Li Tian, Rajkumar Kadaba, Sun-Ah You, Mugen Liu, Ayse Anil Timur, Lin Yang, Qiuyun Chen, Przemyslaw Szafranski, Shaoqi Rao, Ling Wu, David E Housman, Paul E DiCorleto, David J Driscoll, Julian Borrow and Qing Wang. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature, 427 (6975): 640-5, 2004.
  2. Nancy S Wexler, Judith Lorimer, Julie Porter, Fidela Gomez, Carol Moskowitz, Edith Shackell, Karen Marder, Graciela Penchaszadeh, Simone A Roberts, Javier Gay'an, Denise Brocklebank, Stacey S Cherny, Lon R Cardon, Jacqueline Gray, Stephen R Dlouhy, Sandra Wiktorski, Marion E Hodes, P Michael Conneally, Jack B Penney, James Gusella, Jang-Ho Cha, Michael Irizarry, Diana Rosas, Steven Hersch, Zane Hollingsworth, Marcy MacDonald, Anne B Young, J Michael Andresen, David E Housman, Margot Mieja De Young, Ernesto Bonilla, Theresa Stillings, Americo Negrette, S Robert Snodgrass, Maria Dolores Martinez-Jaurrieta, Maria A Ramos-Arroyo, Jacqueline Bickham, Juan Sanchez Ramos, Frederick Marshall, Ira Shoulson, Gustavo J Rey, Andrew Feigin, Norman Arnheim, Amarilis Acevedo-Cruz, Leticia Acosta, Jose Alvir, Kenneth Fischbeck, Leslie M Thompson, Angela Young, Leon Dure, Christopher J O'Brien, Jane Paulsen, Adam Brickman, Denise Krch, Shelley Peery, Penelope Hogarth, Jr, Donald S Higgins, Bernhard Landwehrmeyer and U.S.-Venezuela Collaborative Research Project. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A, 101 (10): 3498-503, 2004.
  3. Thomas A Natoli, Julia A Alberta, Alex Bortvin, Mary E Taglienti, Douglas B Menke, Jan Loring, Rudolf Jaenisch, David C Page, David E Housman and Jordan A Kreidberg. Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol, 268 (2): 429-40, 2004.
  4. Amanda M Shearman, David Karasik, Kristen M Gruenthal, Serkalem Demissie, L Adrienne Cupples, David E Housman and Douglas P Kiel. Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study. J Bone Miner Res, 19 (5): 773-81, 2004.
  5. Jill R Crittenden, Wolfgang Bergmeier, Yanyu Zhang, Crystal L Piffath, Yuqiong Liang, Denisa D Wagner, David E Housman and Ann M Graybiel. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med, 10 (9): 982-6, 2004.

2003

  1. Amanda M Shearman, L Adrienne Cupples, Serkalem Demissie, Inga Peter, Christopher H Schmid, Richard H Karas, Michael E Mendelsohn, David E Housman and Daniel Levy. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA, 290 (17): 2263-70, 2003.
  2. Barbara L Apostol, Alexsey Kazantsev, Simona Raffioni, Katalin Illes, Judit Pallos, Laszlo Bodai, Natalia Slepko, James E Bear, Frank B Gertler, Steven Hersch, David E Housman, J Lawrence Marsh and Leslie Michels Thompson. A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A, 100 (10): 5950-5, 2003.